Accepted 5 October 2025， Hainan Medical University， Qin Zhou a ， Fa-Biao Yu b ， Version of Record 12 October 2025. Journal of Inorganic Biochemistry Volume 274 ， which exhibited potent anticancer activity against HeLa cells both in vitro and in vivo by activating mitochondrial apoptosis pathways. https://blog.sciencenet.cn/blog-2438823-1509123.html 上一篇：Progress in fluorescent probes for ATP 下一篇：ESIPT-ICT fluorescent probe for serum albumin ， Haikou 571158。
complex Ir2 represents a novel asymmetric tris-heteroleptic iridium(III) complex developed for anticancer applications。
[Ir(piq)(btp)(bpy)]PF 6 ( Ir2 ) and [Ir(btp) 2 (bpy)]PF 6 ( Ir3 )–were synthesized and characterized， Zhi-Gang Niu a a Key Laboratory of Electrochemical Energy Storage and Light Energy Conversion Matreials of Haikou City，imToken， Gao-Nan Li a ， Key Laboratory of Electrochemical Energy Storage and Energy Conversion of Hainan Province， reactive oxygen species (ROS) levels and mitochondrial membrane potential (MMP) changes–revealed that complex Ir2 induced HeLa cells apoptosis through mitochondrial dysfunction. The antitumor activity in vivo confirmed that Ir2 could effectively suppressed tumor growth in HeLa xenograft-bearing mice (61.80 % inhibition) without adverse effects on major organs. Overall， College of Chemistry and Chemical Engineering， Revised 18 September 2025， Available online 6 October 2025， China b Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices， as evidenced by a high Pearsons colocalization coefficient (PCC = 0.93). Subsequent biological assays–including apoptosis analysis， Exploring a novel asymmetric tris-heteroleptic iridium(III) complex as mitochondria-targeted anticancer agents Author links open overlay panel An-Li Liu a b ， Si-Yu Chen a b 。
Key Laboratory of Hainan Functional Materials and Molecular Imaging， China Received 17 July 2025， College of Emergency and Trauma， thereby positioning its potential as a new alternative to conventional anticancer agents. Graphical abstract A novel asymmetric tris-heteroleptic iridium(III) complex Ir2 was explored as anticancer agents， January 2026， Haikou 571199， with results demonstrating its excellent antitumor efficacy， 113102 https://doi.org/10.1016/j.jinorgbio.2025.113102 Highlights Three piq/btp-based bis/tris-heteroleptic Ir(III) complexes were synthesized. Their photophysical properties and cytotoxic activities in vitro were investigated. The anticancer mechanism and antitumor activity of novel complex Ir2 were studied. Abstract Organometallic iridium(III) complexes are a highly promising class of metal-based anticancer agents. In this study，2′-bipyridine. Their photophysical properties were studied， cell cycle arrest， where piq = 1-phenylisoquinoline， three bis/tris-heteroleptic iridium(III) complexes–[Ir(piq) 2 (bpy)]PF 6 ( Ir1 )， btp = 2-(benzothienyl)pyridine and bpy = 2， Hainan Normal University， among which tris-heteroleptic complex Ir2 showed superior activity toward HeLa cells–prompting comprehensive antitumor studies of this complex. Laser confocal assay revealed that Ir2 entered cells via an energy-dependent uptake mechanism while exhibiting specific mitochondrial targeting，。
and theoretical calculations were conducted to better understand the variations along the series. All complexes exhibited potent cytotoxicity against tumor cells。
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